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This approach represents a shift from merely targeting individual metabolic pathways to modulating the TME, thereby rendering PDAC more susceptible, disrupting cooperative networks, and preventing escape mechanisms
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As expected, 16S rRNA sequencing demonstrated a persistent increase in microbiome diversity, with predominant growth of Firmicutes and amplification of potentially beneficial phyla not present in SER109 composition, such as Bacteroidetes, for up to 24 weeks after delivery
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