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However, a “real-life”, 500-patient multicenter trial where patients on a strict GFD who still exhibited villous atrophy and abdominal complaints related to CeD were randomized to receive the combined enzymes at different doses versus placebo for 12 or 24 weeks failed to demonstrate a benefit, since both the placebo and the enzyme-treated groups showed a slight improvement [69]

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In addition to mitochondrial oxidative stress and dysfunction, other cellular events may also be potential therapeutic targets for AIH