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Similar protocols are used in humans with both low-grade (i.e., lymphocytic) lymphosarcoma and chronic lymphocytic leukemia.117, 151 Some studies with humans have indicated that continuous therapy with chlorambucil results in prolonged survival, 64 although meta-analyses have not been able to determine optimum dosing and scheduling of administration of chlorambucil or other alkylating agents in these conditions in humans.20, 72 Although we do not have enough data to critically compare pulsed therapy to continuous dosing, the study assessing continuous dosing appeared to have a lower number of cats completely responding, although those cats that did respond had a longer median survival 73 than those in the studies assessing pulsed chlorambucil dosing.43, 84 The differences may also relate to the definitions used for complete response