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[122][Level of evidence C2] Rates of clinically extensive GVHD and treatment-related mortality remain higher after unrelated donor transplant compared with matched sibling donor transplants.[61,78,115] However, there is some evidence that matched unrelated donor transplant may yield a lower relapse rate

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( A ) Representative scatter plots (left panel) of the osmotic fragility test determined by flow cytometry and percentage of RBC lysis (right panel) at 192 mOsm of RBCs from WT and 4.2 –/– mice treated with either vehicle or mitapivat (100 mg/kg/d) for 6 months